Equistar Oral Paste 20g

EQUISTAR® is an oral nematicide-taenicide paste for equines , based on ivermectin, praziquantel and pyrantel pamoate. Praziquantel is the most used anticestodic at the moment. It combines three antiparasitics with recognized therapeutic efficacy.

Ivermectin:

• It acts by potentiating the neuronal inhibitory action of GABA on the central nervous system of nematodes.
• It prevents the transmission of nervous stimulation, causing flaccid paralysis of the parasites.

Praziquantel:

• It is a tenicide that inhibits enzymatic systems of the parasite's carbohydrate metabolism.
• It increases the flow of calcium through the parasite's tegument, causing its vacuolization and disintegration.
• It exposes parasitic antigens, activating the host's defense mechanisms.
• It also alters the metabolism of cestodes, interfering with glucose uptake, lactate release, and glycogen and ATP levels.
• In the animal it is absorbed through the digestive tract and its distribution is very wide in the body, it even passes the blood-brain barrier. The praziquantel spectrum covers all types of tapeworms (adults and young).

Pyrantel pamoate:

• Pyrantel pamoate is a cholinergic agonist nematicide.
• It produces a depolarization of the neuromuscular junction that leads to spastic paralysis and subsequent death of the parasite.

Composition:

Each g of ORAL PASTE contains:

• Ivermectin……………… ……………… 6 mg
• Praziquantel…………………………… 45 mg
• Pyrantel base …………………………. 200 mg
• Excipients csp ………………………….. 1 g